Synthesis and characterization of polyethylene glycol-coated mesoporous maghemite nanoparticles as carriers of anticancer therapeutics in inhalational delivery sSystems

A. Dabbagh, N.H. Abu Kasim, C.H. Yeong, T.W. Wong

Abstract


The iron oxide nanoparticles with superparamagnetic characteristics are potential carriers for utilization in pulmonary drug delivery systems. However, their low surface area leads to insufficient loading capacity for encapsulation or conjugation of diagnostic and therapeutic agents. In this study, we have synthesized maghemite nanoparticles with mesoporous structure using cetyl trimethyl ammonium bromide (CTAB) as template. The synthesized nanoparticles were then coated with a thin layer of polyethylene glycol with molecular weight of 1500 Da (PEG1500) in order to endow thermosensitive characteristics to the nanoparticles and protect their cargo from uncontrolled release. The results showed that although incorporation of CTAB to the synthesis solution led to a significant increase of particle size, however the surface area was also increased from 29 ± 8 to 91 ± 17 m2.g-1, indicating the improved capability of nanoparticles for loading and attachment of different diagnostic and therapeutic compounds. Moreover, the onset phase transition temperature of the protective PEG1500 at 40.4 ± 1.8°C makes these nanoparticles appropriate for application under hyperthermia condition.

Keywords


Maghemite; Surface Area; Hyperthermia; lung cancer; pulmonary delivery

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References


L.A. Torre, F. Bray, R.L. Siegel, J. Ferlay, J. Lortet-Tieulent, A. Jemal, "Global cancer statistics, 2012", CA Cancer J. Clin., vol. 65(2), pp. 87-108, 2015.

Z. Liang, R. Ni, J. Zhou, S. Mao, "Recent advances in controlled pulmonary drug delivery", Drug Discov. Today, vol. 20(3), pp. 380-389, 2015.

K. Darwiche, P. Zarogoulidis, N.K. Karamanos, K. Domvri, E. Chatzaki, T.C. Constantinidis, S. Kakolyris, K. Zarogoulidis, "Efficacy versus safety concerns for aerosol chemotherapy in non-small-cell lung cancer: a future dilemma for micro-oncology", Future Oncol., vol. 9(4), pp. 505-525, 2013.

C.A. Ruge, J. Kirch, C.-M. Lehr, "Pulmonary drug delivery: from generating aerosols to overcoming biological barriers—therapeutic possibilities and technological challenges", Lancet Respir. Med., vol. 1(5), pp. 402-413, 2013.

H.X. Ong, D. Traini, C.-Y. Loo, L. Sarkissian, G. Lauretani, S. Scalia, P.M. Young, "Is the cellular uptake of respiratory aerosols delivered from different devices equivalent?", Eur. J. Pharm. Biopharm., vol. 93, pp. 320-327, 2015.

P. Zarogoulidis, E. Chatzaki, K. Porpodis, K. Domvri, W. Hohenforst-Schmidt, E.P. Goldberg, N. Karamanos, K. Zarogoulidis, "Inhaled chemotherapy in lung cancer: future concept of nanomedicine", Int J Nanomedicine, vol. 7, pp. 1551-1572, 2012.

A. Dabbagh, B.J.J. Abdullah, H. Abdullah, M. Hamdi, N.H.A. Kasim, "Triggering Mechanisms of Thermosensitive Nanoparticles Under Hyperthermia Condition", J. Pharm. Sci., vol. 104(8), pp. 2414-2428, 2015.

A. Dabbagh, B.J.J. Abdullah, N.H. Abu Kasim, H. Abdullah, M. Hamdi, "A new mechanism of thermal sensitivity for rapid drug release and low systemic toxicity in hyperthermia and thermal ablation temperature ranges", Int. J. Hyperthermia, vol. 31(4), pp. 375-385, 2015.

A. Dabbagh, R. Mahmoodian, B.J.J. Abdullah, H. Abdullah, M. Hamdi, N.H. Abu Kasim, "Low-melting-point polymeric nanoshells for thermal-triggered drug release under hyperthermia condition", Int. J. Hyperthermia, vol. 31(8), pp. 920-929, 2015.

A. Dabbagh, N.H. Abu Kasim, M.M. Bakri, H. Wakily, C. Ramasindarum, B.J.J. Abdullah, "Polyethylene-glycol coated maghemite nanoparticles for treatment of dental hypersensitivity", Mater. Lett., vol. 121, pp. 89-92, 2014.

S. Gil, E. Castro, J.F. Mano, "Synthesis and characterization of stable dicarboxylic pegylated magnetite nanoparticles", Mater Lett, vol. 100, pp. 266-270, 2013.


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