Aerosolized nanoemulsion system encapsulating quercertin for lung cancer treatment

N.H. Arbain N.H. Arbain, C.L. Ngan, N. Salim, W.T. Wui, M.B. Abdul Rahman

Abstract


Formulation of aerosol nanoemulsion containing quercetin was carried out using low and high energy homogenizers. The effects of oils (1.0%–4.0% wt%), lecithin (1.0-2.0 wt%) and Tween 80 (0.5–1 wt%) on the droplet size of quercetin nanoemulsions were investigated. The optimum formulation for preparation of quercetin nanoemulsions having the desirable criteria was 1.0 % of oils, 2.0 % of lecithin and 1.0 % of Tween 80 and 95.95 % of aqueous phase. Under optimum formulation, the droplet size was 112.5 nm. Volume median diameter of nanoemulsion in this study was 4.991± 0.008 μm, Span value was 1.662 ± 0.029 and fine particle fraction (% FPF < 5.14 μm) was 55.19 ± 0.153. These results suggest that nanoemulsion -based palm oil in this study could be successful nanocarrier of quercetin as pulmonary delivery system for lung cancer treatment.

Keywords


Aerosol; nanoemulsions; quercetin; lung cancer; pulmonary delivery

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References


World Health Organization Fact Sheet (WHOFS). Availableat:http://www.who.int/mediacentre/factsheets/fs297/en/ (visited July30,2016).

D.A. Kennedy, J. Hart, D.Seely, “Cost effectiveness of natural health products: A systematic review of randomized clinical trials”, Evid-Based Complement Altern Med., vol. 6(3), pp. 297–304, 2009.

S.C. Gupta, S.H. Kim, S. Prasad, B.B. Aggarwal, “Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals”, Cancer Metastasis Rev., vol. 29(3), pp. 405–434, 2010.

Y. Gao, Y. Wang, Y. Ma, A. Yu, F. Cai, W. Shao, & G. Zhai, “Formulation optimization and in situ absorption in rat intestinal tract of quercetin-loaded microemulsion”, Colloids and Surfaces. Biointerfaces, vol. 71(2), pp. 306–14, 2009.

A. Karadag, X. Yang, B. Ozcelik, Q. Huang, “Optimization Of Preparation Conditions For Quercetin Nanoemulsions Using Respon Surface Methodology”, Journal of Agricultural and Food Chemistry, vol. 61, pp. 2130-2139, 2013.

K. Azuma, K. Ippoushi, H. Ito,H. Higashio, “Combination of lipids and emulsifiers enhances the absorption of orally administered quercetin in rats”, J. Agric. Food Chem., vol. 50, pp. 1706−12, 2002.

H. R. F. Masoumi, M. Basri, W.S. Samiun, Z. Izadiyan, & C.J. Lim, “Enhancement of encapsulation efficiency of nanoemulsion-containing aripiprazole for the treatment of schizophrenia using mixture experimental design”, International Journal of Nanomedicine, vol. 10, pp. 6469–6471, 2015.

S. Samson, M. Basri, H. R. F. Masoumi, R.A. Karjiban, & E.A. Malek,“Design and development of a nanoemulsion system containing copperpeptide by D- optimal mixture design and evaluation of its physicochemicalproperties”, RSC Advances, vol. 6, pp. 17845–17856, 2016.

P.H. Li, & W.C. Lu, “Effects of storage conditions on the physicalstability of d-limonene nanoemulsion”, Food Hydrocolloids, vol. 53,pp. 218– 224, 2014.

N.R. Labiris, and M.B. Dolovich, “Pulmonary Drug Delivery Part I:Physiological Factors Affecting Therapeutic Effectiveness Of AerosolizedMedications”, Blackwell Publishing Ltd., British Journal OfClinical Pharmacolology, vol. 56(6), pp. 588–599, 2003.

Bhavna, F.J. Αhmad, R.K. Khar, S. Sultana, A..Bhatnagar, “Techniquesto develop and characterize nanosized formulation for salbutamolsulfate”, J. Mater. Sc.i Mater Med., vol. 20, pp. S71–S76, 2008.

A.Amani, P. York, H. Chrystyn, B.J. Clark, “Evaluation of a Nanoemulsion-Based Formulation for Respiratory Delivery of Budesonide by Nebulizers”, AAPS PharmSciTech., vol. 11(3), pp. 1147- 1151, 2010.


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