Development of poly-ɛ-caprolactone nanoparticles for lung cancer treatment

Faisalina Ahmad Fisol, Habibah Abd. Wahab

Abstract


Nanoparticles (NPs) were developed in this research using poly-ɛ-caprolactone (PCL) biodegradable polymer as nanocarrier for treatment of lung cancer. The optimized PCL nanoparticles formulation were developed by screening the use of different tensioactives (sorbitan monostearate, polysorbate 80, polyvinyl alcohol, sodium caproyl hyaluronate and sodium oleyl hyaluronate) in modified nanoprecipitation method. PCL nanoparticles were then characterized for their physicochemical characteristics such as size and size distribution, surface charge and morphology. Optimised PCL nanoparticles developed in this study gave the best results with particles size 87.84 nm and low PDI of 0.116. The surface charge of the nanoparticles were -24.1 mV. PCL nanoparticles were found stabled up to one month stability in different storage conditions. These results suggested that PCL nanoparticles in this study could be successful nanocarrier for lung cancer hydrophilic drug such as docetaxcel for lung cancer treatment.

Keywords


Poly-ɛ-caprolactone nanoparticles; nanocarrier; pulmonary delivery system; lung cancer

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